Here is the transcript page for episode #7. We continue our discussion with Dr. John Poothullil. We discuss more about insulin sensitivity and resistance, how the body breaks down a meal, statins and their possible effect on diabets and Dr. John’s books and more!
Please visit the full episode page #7 – Dr. John Poothullil Pt. 2 – Insulin Sensitivity, Surviving Cancer, Statins, Books and more for complete show information.
Transcripts may contain a few typos and can be difficult to catch minor errors sometimes.
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Rick Mazur: what did I eat for supper last night? That’s a good question. Let me think about that for a second—a burrito bowl.
Dr. John Poothullil: okay. What was inside
Rick Mazur: Something, you’re not going to like grains, rice beans, black beans, chicken tomatoes.
Dr. John Poothullil: okay. That’s what is made of grains, right? Then that will be digested absorbed into the body as glucose. In a matter of four hours, the meat will be digested and absorbed as fatty acids and cholesterol, because that is what makes them, by the way, I do, The maximum that the body uses the college trough for
Rick Mazur: No.
Dr. John Poothullil: the practice.
The 40, almost the last wash majority of cholesterol, is used as an insulator for the cell war. So if you weren’t registered, cholesterol an animal product, but even vegetarians need cell walls. That is an insulator. In other words, they need they have cholesterol. So I’ll come to that in a minute. The so chicken will be absorbed and absorbed as there will be amino acids because our proteins fatty acids because of fat and cholesterol.
So four hours after a meal, if you take your blood sugar and tested blood glucose and blood and tested like glucose, amino acid, fatty acid, and cholesterol, the glucose elevation will cause the pancreas to release insulin. So insulin glucose, amino acids, fatty acids, and cholesterol will go to every cell in the body.
Insulin will not ring the doorbell, and every cell will accept what they need. So the leftover will come back to the liver, Polish the cholesterol, and put it back into the circulation as either HDL or LDL, the amino acids, any, there is no storage area for an amino acid. So it will be converted into glucose and the excess glue.
The liver will keep 120 grams of glucose. There is no other storage area in the body, so that will be converted into fatty acid. Whether that glucose came from directly from the food or converter, no acid is a fatty acid, and the fatty acid is be went to acid tile coins. I’m a.
And that asset out of coin, Sammy, will be converted into triglyceride. That is the fat we store tri means three molecules of fatty acid. With one molecule of glycerol, the liver will put that into the blood. The blood will take it to the fat sings in the fat cell. The triglyceride is too large. So the molecule gets inside the fat cell outside the fat cell.
There are an enzyme its jobbies or that in some job is to chop down the triglyceride into three molecules of fatty acids. And one molecule of glycerol. So the fatty acid can go inside the fat cell, and the fats are, if it has space to absorb one molecule of glucose from which it produces new glycerol, and it reconstitutes the triglyceride for storage that is the fat we store.
Imagine, if you will, that your fast storage capacity is full, which is the capacity you inherited from your parents. If that is full, what will happen to the triglycerides? That came from the liver. It cannot enter the fat cell. It will stay in the blood, and your blood triglycerides will start going out. If and when the blood Trice triglyceride level is high, the liver sensors, there’s no point in converting excess glucose into fat because the fat can clog up the arteries.
So the liver will stop converting glucose into fatty acid. So then, what will happen to the blood glucose level? It will
Rick Mazur: I don’t know.
Dr. John Poothullil: will start going up. What do you call that person? Yeah. High blood glucose level. Diabetic. So that is what is happening. So you feel inherited a 10-pound fat storage capacity. You can get it filled up, and he can have diabetes. If you have a hundred-pound fast storage capacity, you can gain 80 pounds of weight.
You’re still blood sugar will be normal because there is extra space in the fat cell. Let me give you an example. They say,
Rick Mazur: so this is genetic. Genetic is what you’re saying.
Dr. John Poothullil: but it’s not insulin resistant that you inherit what you’re inserting your fat storage capacity. Let me give you an example. There’s a young lady who becomes pregnant second trimester.
She is diagnosed as gestational diabetic. No previous history of diabetes, no family history of diabetes. What happened? Because when she becomes pregnant, all her friends will say, Okay.
This is good for the complexion of the body of the baby. This is good for height. This is good for the brain.
She eats and eats. She fills up our fat storage capacity, and glucose stays in the blood. She gestationally has diabetes; few days after delivery, she loses weight. Now the fat can be stored in the fat cell, and her diabetes goes away. Does that make sense? The same thing happens when you lose weight, whether the other diabetics, your blood glucose is high.
You lose weight. Now the glucose can be stored as fat. So your bread roll goes, never goes down.
Rick Mazur: Interesting. So are there different signs that people can detect of type two diabetes in men versus women? Or does that not matter?
Dr. John Poothullil: it does not matter. What you have to do is to keep track of your triglyceride level in the blood, in the fasting stage and your fasting blood glucose level; their triglyceride level will start going up way before your fasting blood sugar goes up. Unfortunately, we don’t measure the fatty acids that the muscle can use, but triglyceride and fasting blood sugar.
If we keep track of it every year, you will know if the triglyceride level increases. That means the fat stores are full—the fat staying in the blood. So you are going to be in trouble unless you empty the fat cells.
Rick Mazur: Interesting. That’s good. First of all, I wanted to ask you to go back really quick to something that was asked to me, and many parents have this question. When their children become allergic to things, parents will say they ate something when they were pregnant and could transfer it to the child that caused them to have an allergy. Is there any truth to anything like that?
Dr. John Poothullil: If the protein is transferred from the mother to the baby, the baby’s immune system is formed. If an imprint either tolerance or non-tolerance. So that
is the way it starts.
. we have no way of knowing how that happens. Keep in mind that when the baby is being formed, the people or the enzymes or the people who create the cells are all new to this. Nobody has previous experience making a cell, dividing a cell out, and making all the cell components. So mistakes are common.
Rick Mazur: All right. Can you explain what Statens are and do they cause diabetes
Dr. John Poothullil: that’s a fascinating question because what is happening is. Some endocrinologist prescribed a statin, along with the diabetic medications,
the Staton is ordinarily used or are going to be started to reduce the blood cholesterol level of cholesterol with the fat that can stick to your wall of the artery and course blockade the plaque that produces heart attack, or the stroke is primarily made of cholesterol. Now, where does the cholesterol come from?
All animal products have cholesterol, especially even meat. Meat has got it. If you take one pound of animal fat and one pound of lean animal meat, which one do you think will have more cholesterol? Yeah,
a pound of lean beef will have more cholesterol molecules. Whereas the fat animal fat is saturated, the liver can produce more cholesterol from the animal fat, but the pre-formed cholesterol is more in the meat, the cell wall.
Anyway. So if the witch Darien’s can produce cholesterol that comes from the liver, the Statens, no, there is an assembly line in the liver. The liver is the manufacturing facility for almost all, no many products in the body. So when there is excess glucose, it is converted to acetyl-coenzyme. As I mentioned earlier, that can go to two manufacturing lines, one line for cholesterol, another line for triglyceride; which line it goes to depends on your genetic makeup, the genes that it takes, which line is open.
So if it goes to the cholesterol line, it comes out as cholesterol. So then, the body has to decide how much cholesterol will be needed to produce new cells. So as you get older, the cells get damaged, or the cell has an injury, and the cells are being replaced constantly. So it needs cell war. So it needs insulation, and cholesterol is being used.
The cell wall construction is one molecule of cholesterol, one molecule of fatty acids, one molecule of cholesterol. They alternate. That is how the wall is produced. So it needs cholesterol. That’s the primary use of cholesterol in an adult, even though some cholesterol is used for hormones, sex hormones, for example. Still, the majority of cholesterol is used for cell wall construction.
So to construct, if the cholesterol is outside, the cell needs to know it is outside. So the cell needs to pull it in into the cell to incorporate that into the war. So the all store has to be sticky. It sticks to the cell wall outside. Then the cell gets it in. So you need some sticky, but you don’t want to make all of them sticky because they’ll stick all over the place.
So the liver produces a cap, the protein cap to cap the sticky part, and that cap is made of protein. Eat. Per provides more density. And that cholesterol with the cap is called high density, cholesterol, high density, lipoprotein. That is, the HDL one without the cap is low density. That is the one that can stick you stick the cell surface.
The cell takes it and uses it for construction. Using Statins incapacitates the workers producing the cholesterol molecule that works on the cholesterol line knocks out the workers. So there’s more, the production is reduced. The question you have to ask is then what happens to the raw material the liver was using? That is not going to be used for the construction of cholesterol. Where will they go? Of course, they can be made into fatty acids, and see your muscles are working all the time. Whether you know it or not, there is the tartness of the muscle tone for that. The muscle has to keep on producing energy. Even when you are sleeping, the muscle is still active.
The muscles can use this to produce either glucose or fatty acids that regard your musculature like a hybrid engine in a car that can use gasoline or electricity. So if there is a lot of fatty acid coming because the Staton is blocking the cholesterol production, the muscles can start using fatty acid to produce energy, leaving glucose in the blood.
So over the long term, that person can develop diabetes.
Rick Mazur: but they claim it only happens in a small percentage of the cases,
Dr. John Poothullil: Yes.
Rick Mazur: so I want to move on to your books actually because you’ve written four books, and I want to start with the first one, and we’ll walk through Eat, Chew Live. That was your first book, right?
Dr. John Poothullil: That is correct.
Rick Mazur: What year did you write that book?
Dr. John Poothullil: 2015.
Rick Mazur: And do you explain how the body tries to regulate the nutrient intake and ways to prevent obesity type two diabetes, change your approach to food, and eat a lot of stuff. Good stuff in that book that you wrote.
Dr. John Poothullil: Simpler way to understand is supposing you are thirsty right now. Okay. Rick, you are thirsty. I bring you 12 oz of water.
Rick Mazur: Okay.
Dr. John Poothullil: When you predetermined, how much water will you take to quench your thirst?
Rick Mazur (2): I can…. yes
Dr. John Poothullil: Okay. How much time will it take to drink it? To quench your thirst?
Rick Mazur: 10, 15 seconds,
Dr. John Poothullil: When your thirst is quenched, the water you drank is still in your stomach. Just not being absorbed into the body yet.
Rick Mazur: right?
Dr. John Poothullil: did the brain know you had enough water?
Rick Mazur: It couldn’t have known that quick because the receptors don’t go that quick.
Dr. John Poothullil: Yes, it can and it will, and it should. And it happened that little ice. He won’t stop drinking until your stomach is full and you don’t drink each time. You’re thirsty to the fullness of the stomach. Your stomach capacity is one data more or more as you’re drinking. Suppose I blindfold you. If it’s something to drink, how do you know where it is?
Water or wine or beer or tea? How do you
Rick Mazur: Taste.
Dr. John Poothullil: What I’m suggesting in this book is those taste buds are not only detecting what you are drinking but also metering. How much is going down? The brain already knows your deficit. And when the metering is equal to the deficit, the brain says we had enough, it produces the sensation of quenching, and you stop, and you’re practicing it even now.
Now there is a similar mechanism for nutrients. Also, if you think about nature or the foods that an adult human being can get nutrients from, can you think of a food you can get nutrients from without chewing?
Rick Mazur: cut off.
Dr. John Poothullil: All right. Why did nature do that? No, you have different shapes and colors and sizes all around the world. And all of them are packed with nutrients. A human can live anywhere in the world, but all of them require chewing. Why? Because as you are chewing, the release rate of nutrients is such that their detectors either taste birds or smell receptors can detect monitor meter and tell the brain how much you are eating. I give you an example, suppose you and I go for a buffet hundred items. How many will you choose, let us say, for lunch? How many will you choose?
Rick Mazur: Five
Dr. John Poothullil: or six, based on what
Rick Mazur: variety in what I think will fit on the plate.
Dr. John Poothullil: in other words, it is based on your previous experience, right?
Rick Mazur: Correct. Of course.
Dr. John Poothullil: Because you have enjoyed them
And you sit down V8 read, and then you enjoy dying. Suppose we go back to the same buffet for supper. Will you take the same five you so much enjoy during lunchtime?
Rick Mazur: Probably not because I probably would feel like I wouldn’t have a taste for it.
Dr. John Poothullil: Why do you feel like that?
Rick Mazur: Something in my system is telling me it doesn’t sound good. Something else sounds good.
Dr. John Poothullil: Exactly. The nutrients absorbed after lunch are still in your body. Whereas in the meantime, the cells have used up other nutrients, which the, from your previous experience, your subconscious brain knows which other foods contain those nutrients needed in the body at this time. So it will send a message to a conscious part of the brain.
That one looks more interesting. This one seems appealing, this one you’ll enjoy, and you make a different selection. In other words, your brain can tell you what you should eat. And When the intensity of the enjoyment of that food goes down, you stop and you won’t have a problem with weight.
You won’t have excess consumption. What happens is once you put it on your plate, you are told you don’t waste it because why? Because there are starring people in India and China. So if you eat for them, good for you. Yeah. So, in other words,
Rick Mazur: When you’re younger, especially. I know I tell my kids that as well, but what about adults do it too?
Dr. John Poothullil: exactly, once we get conditioned,
Rick Mazur: Oh, so you’re saying it’s so as an adult, then you’re saying it’s conditioning from childhood, and you’re in, you’re taught to believe that.
Dr. John Poothullil: exactly,
Rick Mazur: So if you go to the movie theater and you order the extra-large popcorn, you’re not hungry for the whole popcorn. You just eat it because you’re conditioned to
Dr. John Poothullil: there is an added factor in a movie theater, or any other entertainment human brain can concentrate only on one thing at a time. Suppose you’re asked to do that math problem. And if we are talking at the same time, you cannot do that. You have to concentrate either on the math problem or on the conversation, right?
Rick Mazur: what about multitasking?
Dr. John Poothullil is at the subconscious level. Once you are trained, women are very good at multitasking because they need to know if the child is crying, see the child or the noise from outside or the dog, or whatever they need to know. Yes. At the subconscious level, you can do that, but you’re not concentrating on it.
Rick Mazur: Not I’m, you’re not concentrating on two things simultaneously.
Dr. John Poothullil: it. So if you’re watching a movie or whether it is in the movie theater or on
The eating becomes secondary, and you may not even enjoy it, but you have to, and you are enjoying it because you are supposed to be doing so you eat not because of in diamond, but because that is what you should be doing.
You paid money for it.
Rick Mazur: I’m not going to dispute that, but I think that’s all habit. Interesting. So you wrote that book in 2015, and what caused you to go onto the next book? The diabetes book. I know you’re, I know you were curious about it. And but why that book and why those specific topics about the book,
Dr. John Poothullil: this one, the first one, was how to prevent type two diabetes and obesity. And what I call the how to maintain authentic way, because all of it can lose weight by cutting down the energy intake of each meal.
Rick Mazur: Okay.
Dr. John Poothullil: once you reach the weight, how do you maintain it? That’s an entirely different formula.
You cannot reduce energy because how do you provide all the other nutrients the body needs? And if you don’t provide that, you get a craving and fall off the wagon, and that’s it. So that is why I wrote this one. Then people came and said, but I already have diabetes. How can I prevent it if I already have it? So that is what forced me to produce—this one. Debit is the actual cost. That is when I started looking deeper into the insulin resistance hypothesis. And I could not find any evidence of validation. I have, send my concern to 50 different endocrinologists, and 49 did not answer one answer. And she said we are on the verge of having the whole mystery. Verified, and I’m still waiting for it.
Rick Mazur: And that’s where you say that it over-consuming grains and things like that. There are other reasons for it.
Dr. John Poothullil: 60 years ago, we had the agricultural revolution or the green revolution, and grain farming became very easy. Every government-subsidized grain farming, direct subsidy, fertilizer subsidy, food subsidy, and grains are the cheapest pre-packaged convenience foods. When is the last time you had a meal or a snack without a grain-based product? So the previous 60 years, it had been happening. Fifty years ago, we started the obesity epidemic. Ten years later, we started the Diabetic epidemic. We are in the cancer epidemic that is all a continuation of the same problem. We are putting more glucose into the system than the system can tolerate, and it is coming out differently in different people.
Rick Mazur: I’ve been thinking about this for probably five or ten years now. And I’ve always said something had to change in the world, either the air you breathe or the food you eat. That’s the only thing going into your system that could be causing all this cancer. Now, suddenly, how come there wasn’t this rate of cancer years ago? Something changed. And people talk about GMOs and different things like that, but maybe it can be solved on a bit simpler level. And perhaps that has something to do with it too. I don’t know. That’s a different discussion, but people need to look more at this grain thing and get your book and stuff like that because they can probably get a lot more information. Then you wrote your third book, surviving cancer. Why does cancer happen in adults?
Rick Mazur (2): What year was that? 20, 19 to 2019. And that one’s dear too near and dear to my heart. Cause I lost both of my parents to cancer. I have not read that book of yours. But we’re talking about that sometimes cancer is happening in adults because of the lifestyle.
And is that basically what the consensus of the book is? So people need to eat healthier and stuff like that.
Dr. John Poothullil: The first thing to understand is the human body is used to cancer cells. Even before we are born, the maximum number of pre-cancerous cells in the body is when you are in the mother’s womb. Keep in mind that.
People who are constructing cells are all new to this. They make mistakes after mistakes or lots of pre-cancerous cells, but the immune system destroys 99% of them.
Before you are born, in other words, the human body’s used to killing cancer cells. So you are exposed to cancer cells right from the get-go. And we all, in that respect, are all cancer survivors. In my opinion, cancer cells are still being produced. Whenever there is lapping multiplication of cells, as in chronic inflammation, cells are dying, and new ones are produced.
Somebody who has a colon issue, interpersonal issues, or lung issues get cancer more quickly because no new cells are formed, and mistakes made cancer cells formed. However, the immune system can destroy them unless the rate of cancer, cell multiplication, alarms, the rate of destruction by the immune system. Suppose the immune cells can kill 1000 cancer cells an hour, but the production line is 1,100 and wins the war. That is what is happening, and how do the cancer cells do that? Because they need to fabricate a new cancer cell, it requires materials. It needs power, and it needs a booster. The glucose provides not only the. Energy, but also the materials because the glucose molecules can be fashioned. It, the cancer cell does not need all the energy in glucose cell—only 10%. The rest can be used for construction material. And if you have an enzyme-like Insulin, Insulin is released when the blood glucose level goes down.
Insulin is a promoter. It promotes all activities of the cell insulin cannot make a value judgment. What the cell is doing, good or bad. If it is producing COVID-19 insulin, say produce more. If it produces or cancer cells, insulin separately is more, so people with diabetes are not more prone to catch COVID-19, but they will suffer more because they make more.
COVID-19 you, they are more prone to get cancer.
Rick Mazur: no.
Dr. John Poothullil: Insulin promotes cancer growth and provides the glucose that is already there.
Rick Mazur: That’s why they talk about the pre-existing conditions and multiple pre-existing conditions. They always say, if you have multiple pre-existing conditions, watch out, but they don’t ever explain to you why, and that’s important stuff. Now let’s get to the newest book, cause this is your newest one.
God forbid, when your child has cancer, I hope I don’t even want to think about that, but it happens to people. And you mentioned something interesting here, and I guess it wouldn’t occur to people unless they have a medical background. You’re talking about why it happens, given that children haven’t lived long enough to develop the gene mutations.
That usually causes cancer in adults. So why does it happen in children?
Dr. John Poothullil: well, ordinarily, an adult is told you’re accumulating mutations as you get older, and it takes six decades of accumulation of mutations for you to have a cancer stem cell is the mother cell that produces babysits. So if it takes six decades, when I was talking to a cancer hospital staff, one of the oncologists stood up and said, Dr.
John. It takes six decades for adults to develop a cancer cell. And the child, the average age of a child with cancer is six. How is cancer possible? That started me thinking there is something else going on here now, so let’s understand cancer. Cancer is uncontrolled multiplication. The cancer cells are not functional. They don’t perform a physiological function. All they are interested in is producing more numbers. Okay. So how to understand that, we need to know what is a controlled multiplication. Let us say you get a wound, a cut in the skin. How does it heal? There are stem cells which are mother cells at the base of the skin. They get their message from the cells that are missing their neighbors because they’re lost the neighbor. So they send a message to the mother’s cell. My neighbor is missing. So that message come comes to the stem cell from outside.
So the stem cell will be producing a new sense when the neighbors are. So the hearing starts from both ends. So the wound on both sides meets in the middle, and the message is sent to the stem setup. My neighbors are back. We don’t need it so that there won’t be any demand going down. So the absence of Cigna, the stem cell stop reproduction. So that the message produces the activity, and the lack of message stops the activity. Healing is taking place in cancer. The signal for multiplication is produced inside. What does that mean? The best example is you and me, you and we at all; we both were formed from a single cell after fertilizing an ovum.
You’ve got one single cell called Zeigarnik. Do you know where that fertilization takes place? It does not take place in the womb. It takes place in the fallopian tube. As the ovum travels down the ovary to the womb, it takes six days of the journey before it is implanted in the womb.
How many cells are there in that implant? 200 cells.
Rick Mazur: Okay.
Dr. John Poothullil: the psych ward is moving. It is not getting any signals from outside. How does it divide? It has to be an internal signal. So each of these 200 selves is capable of dividing based on internal signaling. And each one is will be assigned to an organ or a system in the body to be the stem cells for, to produce the number of cells needed in that organ or the body. I’m suggesting that if that stem cell goes into the wrong place in the body or does not get connected to the neighbors or something goes wrong with its power production facility; it can revert into the ancestor’s inherited way of responding to it; an internal signal and start multiplying.
Rick Mazur: Your book talks about more of that in-depth and will help parents learn how to. Help with diet and different things like that to help control things
Dr. John Poothullil: exactly.
Rick Mazur: That’s great. That’s
Dr. John Poothullil: when your child is diagnosed with cancer, you feel helpless. You are stressed; you’re anxious. You’re fearful. My position is most of that unhappiness and stress come from what you don’t know. If you understand it, then you are at least helping the child.
Otherwise, you are at the mercy of the doctor. Do you just follow without understanding what you are doing? Why are you? How can you help the child get over this? So that is the message in that book that you can be supportive. You can be an active parent, not only following the instruction, I’m not suggesting that you should not follow the instructions, but you can know
Rick Mazur: Of course.
Dr. John Poothullil: more so that the number of medications used by the oncologist can be reduced.
That is 60% of the cancers; childhood cancer survivors will have complications in later life, which is directly proportional to the treatment dosage. So if we can reduce the treatment, you will get the reward later on down the line.
Rick Mazur: fascinating. Fascinating. This is a lot of information, Dr. John. I want to thank you for being on the show. I think we got a lot of good stuff here, and people will check this stuff out. We’re going to link to your website, which is Dr. John on health.com, and we’ll link to all the books and everything in the show notes on the webpage.
And, of course, I’m sure people can reach out to you. Can they reach out to you from the webpage? If they have any questions
Dr. John Poothullil: And all global salivate level on Amazon.
Rick Mazur: Okay. Yeah, we’re going to link to them and everything like that as well. And boy, it was great having you. You have given a whirlwind of information that I’m sure people will enjoy.
Dr. John Poothullil: and I thank you and people like you for spreading the message. I don’t sell anything on my website. I’m not promoting; I’m all I’m giving is my opinion. I can take it or leave it as long as they understand it. It is theirs.
Rick Mazur: And we all have to read to get the knowledge, and we make up our own decisions and we. All right, Dr. John, again, it’s been great. Have a great day, and we’ll talk to you next time.
Dr. John Poothullil: thank you for having me, and I thank all our listeners.
Rick Mazur: All right. Bye. Bye.